Shepherdstown is situated in eastern West Virginia, convenient to Washington, D.C., and to many nearby cities in West Virginia, Virginia, Maryland, and Pennsylvania. If you're driving, here are some of the most frequently used routes to the campus.

From the North or South 
Follow Interstate 81 to Martinsburg, West Virginia, and take Exit 16 East (Route 9 East) into Martinsburg. Turn left onto Route 45 East, and follow Route 45 into Shepherdstown. Proceed through the four-way stop sign.

 From the West
 Follow Interstate 70 East to Hagerstown, Maryland. In Hagerstown follow Interstate 81  South  to Martinsburg, West Virginia, and take Exit 16 East (Route 9 East) into Martinsburg.  Turn left onto Route 45 East, and follow Route 45 into Shepherdstown. Proceed through the  four-way stop sign.

 From the East 
 Follow Interstate 70 or 270 West from Baltimore, Maryland or Washington, D.C., to  Frederick,  Maryland, and take Exit 49 (alternate Route 40 West). Follow Alternate Route 40  through Middletown to Boonsboro, Maryland. In Boonsboro turn left onto Route 34, and follow  Route 34 through Sharpsburg across the Potomac River into Shepherdstown. Turn left at the  four-way stop sign onto Route 45 (German Street).

 When you get to Shepherdstown, proceed two more blocks on German Street to King Street,  the main street of the Shepherd campus